Research & Development

Projects & Publications

Exploring the spatial universe of cells through computational methods, open-source tools, and collaborative research.

Publications

iScience • 2026

Integrative spatial multi-omics reveal niche-specific inflammatory signaling and differentiation hierarchies in AML

Comprehensive spatial transcriptomic profiling revealing cellular neighborhoods in acute myeloid leukemia bone marrow samples.

Spatial Multi-OmicsAMLBone Marrow

BioRxiv • 2025

Macrophage-secreted Pyrimidine Metabolites Confer Chemotherapy Resistance in Acute Myeloid Leukemia

Identifying a metabolic immune-leukemia crosstalk in which SAMHD1 high macrophages mediates chemoresistance by secreting pyrimidine metabolites.

scRNA-seqHSCNiche Dynamics

npj Precision Oncology • 2025

Multimodal spatial proteomic profiling in acute myeloid leukemia

Novel computational framework for integrating spatial proteomics and transcriptomics data in cancer research.

Multi-modalPipelineIntegration

Leukemia & Lymphoma • 2024

Mutation dynamics from diagnosis to relapse in acute myeloid leukemia with chromosomal 7 deletions

Mutation dynamics from diagnosis to relapse in acute myeloid leukemia with chromosomal 7 deletions.

AMLMutation DynamicsChromosomal 7 Deletions

Nature Communications • 2024

Comprehensive characterization of IFNγ signaling in acute myeloid leukemia reveals prognostic and therapeutic strategies

Inhibiting IFNγ signaling is a potential treatment strategy to overcoming venetoclax resistance and immune evasion in AML patients.

ImmunologyTMESingle Cell Analysis

Symposiums & Conferences

Oral Presentation

American Society of Hematology (ASH) • 2024

Multimodal Spatial Transcriptomic Profiling Elucidates Niche-Specific Dynamics in Medullary and Extramedullary Acute Myeloid Leukemia

Presented novel findings on spatial organization of the bone marrow niche in acute myeloid leukemia using integrated multi-omics approaches.

View Abstract

Oral Presentation

European Hematology Association (EHA) • 2025

Integrative Spatial Multi-Omics Reveal Niche-Specific Inflammatory Signaling and Differentiation Hierarchies in Acute Myeloid Leukemia

Presented novel findings on spatial organization of the bone marrow niche in acute myeloid leukemia using integrated multi-omics approaches.

View Abstract

Software & Tools

⭐ 124

SpatialOmics Toolkit

Python package for comprehensive spatial transcriptomics analysis including cell segmentation, spatial statistics, and visualization.

PythonSpatial Analysis

Code

⭐ 87

CellNeighborhood

R package for identifying and characterizing cellular neighborhoods in spatial omics data.

RBioconductor

Code

⭐ 56

MultiOmicsIntegrator

Web-based tool for integrating and visualizing multi-modal single-cell and spatial datasets.

ReactWebGL

Code Demo

⭐ 43

NicheMapper

Interactive visualization platform for exploring cellular niches and microenvironments in tissue sections.

D3.jsPython

Code Demo

Interested in Collaboration?

I'm always looking for new research collaborations and opportunities to apply computational methods to biological questions.

Let's Talk